Hong Kong is a natural laboratory for studying suicides—small geographic footprint, bustling economic activity, rapidly changing socio-demographic transitions, and cultural crossroads. Its qualities also serve to intensify the challenges posed when seeking to prevent them. The Hong Kong Jockey Club Centre for Suicide Research and Prevention (CSRP) was established in 2002 in response to rapidly increasing, local suicide rates. CSRP adopted a multi-level public health approach (universal, selective and indicated), and has collaboratively designed, implemented, and evaluated numerous programs that have demonstrated effectiveness in suicide prevention and mental well-being promotion. Centers such as CSRP can serve as a hub and a catalyst for creating or identifying, deploying, and evaluating suicide prevention initiatives, which together have the potential to reduce regional suicides rates when taken to scale and sustained. This requires committed collaboration involving governments, local community partners, and academic institutions. Some discussions on the implications and generalizability are provided.